"Ah yes, Reapers..."

It seems that even in Los Santos, dismissing those claims would be a mistake. The ancient harbingers of our destruction have arrived in Blaine County, and the full invasion will soon follow.
Mass Effect, a legendary Sci-Fi RPG developed by Bioware and lauded for its story (the endings were fine, dammit!), follows the exploits of one Commander Shepard, who seeks to thwart the imminent destruction of galactic civilization by way of giant space shellfish who speak dramatically and shoot lasers at stuff. These so called Reapers, massive sentient spaceships, return to the galaxy from dark space every few million years to destroy all technologically advanced societies because spoiler.