The Los Santos Drug Wars update adds six First Dose missions and five Last Dose missions to GTA Online. Completing First Dose unlocks the Acid Lab business, while Last Dose concludes the Fooliganz storyline.

Ron Jakowski calls after you enter GTA Online following the update. That call begins the First Dose sequence, which provides the Brickade 6x6 needed to establish the Acid Lab.

First Dose Mission Overview

"First Dose" is the name of the six-mission storyline that you must complete to unlock the Acid Lab business. These missions can be started after receiving a call from Ron Jakowski, which you will receive after logging into GTA Online the first time since the Los Santos Drug Wars update arrived on December 13, 2022.

Once you've received Ron's call, you can go to the 'R' marker (representing Ron Jakowski) on your map. You can find it at Paleto Bay in Blaine County.

This is where you will start your first mission of the First Dose series called 'Welcome to the Troupe'.

Navigate through our walkthroughs for each mission in "The First Dose" series, followed by a guide to setting up and running your Acid Lab:

First Dose Missions Guide

First Dose 1: Welcome to the Troupe

First Dose 2: Designated Driver

First Dose 3: Fatal Incursion

First Dose 4: Uncontrolled Substance

First Dose 5: Make War not Love

First Dose 6: Off the Rails

The Acid Lab Business

After completing all the First Dose missions above, learn all about your Acid Lab business, including how to set it up, understand its mechanics, purchase upgrades (including the essential equipment upgrade via Fooligan Jobs), and maximize your production and sales.

The Last Dose Mission Overview

The second part of the Los Santos Drug Wars DLC contains five missions and is called "The Last Dose." It concludes the story which features characters like Dax, Labrat, Luchadora, and the infamous Isiah Friedlander from GTA 5's story mode.

Below, we have guides to completing all five missions of The Last Dose. They're not difficult to complete, but they do require some form of preparation, including buying snacks and armor, as all missions contain a lot of combat.

To start The Last Dose missions, you must complete all six Dose Missions Guide|The First Dose missions] (above). After completing the first six missions, you will receive a call from Dax.

After the call, you can start the mission by visiting 'D' outside the Freakshop. The letter 'D' represents Dax.

The Last Dose Missions Guide

Here's all our walkthroughs for The Last Dose missions:

Last Dose 1: This is an Intervention

Last Dose 2: Unusual Suspects

Last Dose 3: Friedmind

Last Dose 4: Checking In

Last Dose 5: BDKD

Frequently Asked Questions

If you still have questions, we have a Los Santos Drug Wars and the Acid Lab FAQ.

Begin your journey with Welcome to the Troupe and work your way through The First Dose to unlock one of GTA Online's most unique and profitable businesses, then carry on and finish the entire DLC with the Last Dose.