Jimmy Kimmel's show, whatever your opinion may be of the man, is certainly an influential aspect of popular culture. Of the many returning segments used during the run of the show, one of the most popular is where various celebrities sit down and read mean, angry or offensive tweets that are aimed at them, and then react.
While some of this can turn out quite funny, these are celebrities we are talking about, so most of the segment is pretty drab. If one were to switch them out for, say, various characters from the story of GTA V, you'd get more interesting reactions, yes?
Well, not really. Not to say that this isn't miles ahead of talk shows, it's just that it shines in the "tweets" themselves, and less the reactions. Most responses are simply some variation of "thanks", though near the end there is some variety with Lamar and Lloyd.