Charleston is also known for a large military presence. The former naval shipyard was the third-largest of its kind. Since it's closure and transfer to civil hands, it has become the largest commercial shipyard on the eastern coast, operated by Detyens Shipyards. Though it is no longer a military installation, the shipyard still mostly takes on military contracts.
Joint Base Charleston today houses almost 80,000 servicemen, and the base now stores the over 2,500 nuclear warheads which were formerly used to outfit the nuclear-capable submarines which docked at the former naval base.
Charleston also often suffers from the violent coastal weather. While it is only rarely hit full on by hurricanes, it does take some damage from their near passes. The most destructive natural disaster to hit Charleston was caused by Hurricane Hugo in 1989.
Charleston also made international headlines in the summer of 2015 when a deadly and deplorable hate-crime caused the death of 9 people. A lone gunman, 21-year-old "white-supremacist" Dylann Roof, who was also a drug user, school dropout and unemployed, attacked the Emanuel African Methodist Episcopal Church.
Crime
Beyond the above mentioned tragedy, Charleston has a pretty high rate of crime compared to its size and population. It has the fourth highest murder rate in its category, and sits well above the national averages in pretty much every category. Violent crime is generally higher than in other cities this small. While gangs and organised crime are more subtle in the city, they are certainly present.
The busy port makes Charleston a prime location for smuggling and trafficking. Being a smaller city, it isn't as tightly controlled, and under-the-table deals draw less attention. The city is one of the seldom mentioned gateways of illegal goods in an out of the country.
The city's history, in spite of best efforts to break from it, still hang over it regardless. Discrimination and hate crimes are generally more common in Charleston than in other cities of its kind to the north.
Recognition
While Charleston will be pretty easily recognized by players hailing from the USA due to it being a favored national tourist attraction, and due to its importance in the history of the nation, I'm banking on foreign players not being too familiar with it. The most iconic part of its skyline is that its extremely reserved with pretty much no tall buildings to speak of, and it might be the only USA city of its size where the cityscape is dominated by church towers.
As a result, most of the notable buildings in the city are, in fact, churches. Churches of pretty much all Christian denominations can be found scattered around the old-city. In terms of non-church landmarks, the Pink House, the Gibbes Art Gallery and the City Hall are probably best known. Though it is hardly a tourist attraction, the large port is also a strong characteristic of Charleston. It's coastal area and beaches, on the other hand, are favored by visitors.
Story Potential
The game could focus on a small-time crime group with a hand in smuggling and trafficking through the port trying to take over both the tourism industries by extorting hotels, restaurants and souvenir shops, while also attempting to get a leg into the growing IT business. In fact, the story could be cut up into 3 acts.
In act 1, you have to deal with a rival syndicate who also has a hand in illegal smuggling, cementing yourself as the kingpin when it comes to blackmarket goods. In act 2, you'll try to muscle your way into the tourism business, by blackmailing hotel owners into paying you protection fees, wrecking restaurants which defy you and make deals with shops to sell the goods your smuggling ring brings in.
In the final third act, you'll try to somehow get a slice of the tech and IT pie. While in the first two acts, you'll be up against other criminals, a private security company takes care of the high profile corporations, meaning you'll be fighting tougher and better equipped enemies. Eventually, you'll impose one of your subordinates as the CEO of a major company, making you the true kingpin of Charleston.
Final Verdict
A-Pros: Geography, crime rate, story potential
Cons: Poor international recognition
Overall, Charleston fares really well as a GTA setting, with great geographic characteristics, decent crime rates and some solid story potential. Plus, most people in the USA would likely recognize the city off-hand. That said, it's a pretty good bet that most foreign players would have no clue about which city the setting is based on, unless it's explicitly stated.
Would you like to play a GTA game set in Charleston?